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Publications |
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within categories publications are listed in reversed chronological order Please send a request for reprint(s) by e-mail |
DISSERTATION
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Blokland, A. (1992). Animal models of cognitive aging and dementia: problems and perspectives. Maastricht, DataWyse Publishers.
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REVIEWS
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1. van der Staay, F.J., Rutten, K., Erb, K. & Blokland, A. (2011). Effects of the cognition impairer MK-801 on learning and memory in mice and rats. Behavioural Brain Research, 220, 215-229. 2. van Donkelaar, E.L., Blokland, A., Ferrington, L., Kelly, P.A.T., Steinbusch, H. & Prickaerts, J. (2011). Mechanism of acute tryptophan depletion: Is it only serotonin? Molecular Psychiatry, 16, 695-713 3. Klinkenberg, I., Sambeth, A. & Blokland A. (2011). Acetylcholine and attention. Behavioural Brain Research, 221, 430-42 4. Klinkenberg, I. & Blokland, A. (2010). The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies. Neuroscience & Biobehavioral Reviews, 34, 1307-1350. 5. Lim, L.W., Blokland, A., Visser Wandevalle, V., Steinbusch, H. & Temel, Y. (2009). The Periaqueductal Gray: From Longitudinal columns to defensive behaviour. Journal of Experimental and Clinical Medicine, 26, 1-26. 6. Reneerkens, O.A.H., Rutten, K., Steinbusch, H., Blokland, A. & Prickaerts (2009). Selective phosphodiesterase Inhibitors: a promising target for cognition enhancement. Psychopharmacology, 202, 419-443. 7. Blokland, A. & Boess, F. (2008). Use of behavioral and LTP models in the development of memory-improving drugs. Expert Opinion on Drug Discovery, 3, 1067-1080. 8. Sambeth, A., Blokland, A., Harmer, C.J., Kilkens, T.O.C., Nathan, P.J., Porter, R.J., Schmitt, J.A.J., Scholtissen, B., Sobczak, S., Young, A.H. & Riedel, W.J. (2007). Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies. Neuroscience & Biobehavioral Reviews, 31, 516-529. 9. Jans, L.A.W., Riedel, W.J., Markus, C.R. & Blokland, A. (2007). Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Molecular Psychiatry, 12, 522-543. 10. Tan, S.K.H., Temel, Y., Blokland, A., Steinbusch, H.W.M., & Visser-Vandewalle, V. (2006). The subthalamic nucleus: From response selection to execution. Journal of Chemical Neuroanatomy, 31, 155-161 11. Blokland, A., Schreiber, R. & Prickaerts, J. (2006). Improving memory: a role for phosphodiesterases. Current Pharmaceutical Design, 12, 2511-2524. 12. Temel, Y., Blokland, A., Steinbusch, H., & Visser-Vandewalle, V. (2005). The functional role of the subthalamic nucleus in cognitive and limbic circuits. Progress in Neurobiology, 76, 393-413. 13. Prickaerts J., Şık, A., van Staveren, W., Koopmans, G., Steinbusch, H.W.M., van der Staay, F.J., de Vente, J., & Blokland, A. (2004). Phosphodiesterase type 5 inhibition improves early memory consolidation of object information. Neurochemistry International, 45, 915-928. 14. Prickaerts, J., Koopmans, G., Blokland, A., & Scheepens, A. (2004). Learning and neurogenesis: Survival with or without proliferation. Neurobiology of Learning and Memory, 81, 1-11. 15. Deumens, R., Blokland, A., & Prickaerts, J. (2002). Modelling Parkinson’s disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Experimental Neurology, 175, 303-317. 16. Van der Staay, F.J., Fanelli, R., Blokland, A., & Schmidt, B.H. (1999). Behavioral effects of apamin, a selective inhibitor of the SKCa-channel, in mice and rats. Neuroscience & Biobehavioral Reviews, 23, 1087-1110. 17. Blokland, A. (1998). Reaction time responding in rats. Neuroscience & Biobehavioral Reviews, 22, 847-864. 18. Blokland, A. (1996). Acetylcholine: A neurotransmitter involved in learning and memory processes ? Brain Research Reviews, 21, 285-300. 19. Raaijmakers, W., Blokland, A., & Van der Staay, F.J. (1993). Spatial discrimination learning in rats as an animal model of cognitive ageing. Behavioural Processes, 30, 165-174.
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LETTERS |
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1. Sambeth, A., Meeter, M., & Blokland, A. (2009). Hippocampal theta frequency and novelty. Hippocampus, 19, 407-408.
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RESEARCH
PAPERS
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First
author 1. Blokland, A., Rutten, K., & Prickaerts, J. (2006). Analysis of spatial orientation strategies of male and female Wistar rats in a Morris water escape task. Behavioural Brain Research, 171, 216-224. 2. Blokland, A., Şık, A. & Lieben, C. (2005). Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats. Behavioural Pharmacology, 16, 93-100. 3. Blokland, A., Şık, A. & van der Staay, F.J. (2004). Delayed non-matching to position performance in aged hybrid Brown NorwayxFischer 344 rats: a longitudinal study. Brain Research Bulletin, 64, 39-46. 4. Blokland, A., Lieben, C. Deutz, N.E.P. & Schmitt, J. (2004). Acute tryptophan depletion: comparing the effects of an amino acid mixture with a gelatin-based protein in man and rat. Current Topics in Nutraceutical Research, 2, 161-168. 5. Blokland, A., Geraerts, E. & Been, M. (2004), A detailed analysis of rats’ spatial memory in a probe trial of a Morris task, Behavioural Brain Research, 154, 71-75. 6. Blokland, A., Broersen, L.M., Uylings, H.B.M. & Jolles, J. (2003). Intact spatial discrimination performance but impaired reaction time performance after frontal cortex lesions in the rat. Neuroscience Research Communications, 33, 1-16. 7. Blokland, A., Lieben, C. & Deutz, N. (2002). Anxiogenic and depressive like symptoms, but no cognitive deficits after acute tryptophan depletion in the rat. Journal of Psychopharmacology, 16, 39-49. 8. Blokland, A., Scholtissen, B., Vermeeren, A. & Ramaekers, J. (2001). Dissociable effects of histamine H1 antagonists on reaction time performance in rats. Pharmacology Biochemistry and Behavior, 70, 427-436. 9. Blokland, A., Honig, W., & Jolles, J. (2001). Long-term consequences of repeated anesthesia on reaction time performance in ageing rats. British Journal of Anaesthesia, 87, 781-783. 10. Blokland, A., De Vente, J., Prickaerts, J., Honig, W., Markerink-van Ittersum, M., & Steinbusch, H. (1999). Local inhibition of hippocampal nitric oxide synthase does not impair place learning in the Morris water escape task in rats. European Journal of Neuroscience, 11, 223-232. 11. Blokland, A. & Honig, W. (1999). Intra-striatal haloperidol and scopolamine injections: effects on choice reaction time performance in rats. European Neuropsychopharmacology, 9, 523-531. 12. Blokland, A., Honig, W., Brouns, F. & Jolles, J. (1999). Cognition enhancing properties of subchronic bovine cortex, egg, and soy phosphatidylserine in middle-aged rats. Nutrition, 15, 778-783. 13. Blokland, A. (1998). Involvement of striatal cholinergic receptors in reaction time and fixed interval responding in rats. Brain Research Bulletin, 45, 21-25. 14. Blokland, A., Honig, W. & Prickaerts, J. (1998). Effects of haloperidol and amphetamine on working memory and reference memory in a spatial cone field task. Behavioural Pharmacology, 9, 429-436. 15. Blokland, A., Prickaerts, J., Honig, W. & de Vente, J. (1998). State-dependent impairment in object recognition after hippocampal NOS inhibition. NeuroReport, 9,4205-4208. 16. Blokland, A. & Dunnett, S.B. (1995). Development of response tendencies in the initial training trials of a (non)matching to position task: Consequences for learning the (non)matching to position task contingencies. Psychobiology, 23, 76 84. 17. Blokland, A., Hinz, V. & Schmidt, B.H. (1995). Effects of metrifonate and tacrine in the spatial Morris task and modified Irwin test: evaluation of the efficacy/safety profile in rats. Drug Development Research, 36, 166-179. 18. Blokland, A., Honig, W. & Raaijmakers, W. (1994). Age-related changes in spatial discrimination learning performance in old Lewis rats. Psychobiology, 22, 149-155. 19. Blokland, A. & Jolles, J. (1994). Behavioral and biochemical effects of streptozotocin in old Lewis rats. Pharmacology Biochemistry and Behavior, 47, 833-837. 20. Blokland, A., Bothmer, J., Honig, W. & Jolles, J. (1993). Behavioural and biochemical effects of acute central metabolic inhibition: effects of acetyl-l carnitine. European Journal of Pharmacology, 235, 275-281. 21. Blokland, A. & Jolles, J. (1993). Spatial learning deficit and reduced hippocampal ChAT activity after an i.c.v. injection of streptozotocin. Pharmacology Biochemistry and Behavior, 44, 491-494. 22. Blokland, A., Prickaerts, J. & Raaijmakers, W. (1993). Absence of impairments in spatial and temporal discrimination learning in Lewis rats after chronic ethanol consumption. Pharmacology Biochemistry and Behavior, 46, 27-34. 23. Blokland, A. & Raaijmakers, W. (1993) Age-related changes in correlation between behavioral and biochemical parameters in Lewis rats. Behavioral and Neural Biology, 60, 52-61. 24. Blokland, A. & Raaijmakers, W. (1993). Food motivation in rats of different ages. Psychobiology, 21, 228-232. 25. Blokland, A., Honig, W. & Raaijmakers, W. (1992). The effect of intra hippocampal scopolamine injections in a repeated spatial acquisition task. Psychopharmacology, 109, 373-376. 26. Blokland, A., Raaijmakers, W., Honig, W. & Van der Staay, F.J. (1992). Spatial discrimination learning and orientation strategy in young and old Lewis rats. Neuroscience Research Communications, 10, 105-110. 27. Blokland, A., Prickaerts, J. & Raaijmakers, W.G.M. (1992). Reduced level of anxiety in adult Lewis rats after chronic ethanol consumption. Physiology & Behavior, 51, 245-248. 28. Blokland, A., Raaijmakers, W., Van der Staay, F.J. & Jolles, J. (1990). Differential effect of acetyl-l-carnitine on open field behavior in young and old rats. Physiology & Behavior, 47, 783-785.
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RESEARCH PAPERS |
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Co-author 1. Rutten, K., Wallace, T.L., Works, M., Prickaerts, J., Blokland, A., Novak, T.J., Santarelli, L. & Misner, D.L. (2011). Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B knockout (PDE4B-/-) mice. Neuropharmacology, 61,138-47. 2. Vanmierlo, T., Rutten, K., van Vark-van der Zee, L.C., Friedrichs, S., Bloks, V.W., Blokland, A., Ramaekers, F.C., Sijbrands, E., Steinbusch, H., Prickaerts, J., Kuipers, F., Lütjohann, D. & Mulder, M (in press). Cerebral Accumulation of Dietary Derivable Plant Sterols does not Interfere with Memory and Anxiety Related Behavior in Abcg5-/- Mice. Plant Foods for Human Nutrition. 3. Klinkenberg, I. & Blokland, A. (2011). A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment. Psychopharmacology, 215, 549-566. 4. Lim, L.W., Blokland, A., van Duinen, M., Visser-Vandewalle, V., Tan, S., Vlamings, R., Janssen, M., Jahanshahi, A., Aziz-Mohammadi, M., Steinbusch, H., Schruers, K. & Temel Y. (2011). Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats. Behavioural Brain Research, 218, 301-307. 5. Berbée, J.F., Vanmierlo, T., Abildayeva, K., Blokland, A., Jansen, P.J., Lütjohann, D., Gautier, T., Sijbrands, E., Prickaerts, J., Hadfoune, M., Ramaekers, F.C., Kuipers, F., Rensen, P.C.& Mulder, M. (in press). Apolipoprotein CI Knock-Out Mice Display Impaired Memory Functions. Journal of Alzheimers Disease. 6. Lim, L.W., Blokland, A., Tan, S., Vlamings, R., Sesia, T., Mohammadi, M.A., Visser-Vandewalle, V., Steinbusch, H.W.M., Schruers, K. & Temel, Y. (2010). Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray. Experimental Neurology, 226, 293-300. 7. Sesia, T., Bulthuis, V., Tan, S., Lim, L.W., Vlamings, R., Blokland, A., Steinbusch, H.W., Sharp, T, Visser-Vandewalle, V. & Temel, Y. (2010) Deep brain stimulation of the nucleus accumbens shell increases impulsive behavior and tissue levels of dopamine and serotonin. Experimental Neurology, 225, 302-309. 8. van Donkelaar, E., Kelly, P.A.T., Dawson, N., Blokland, A., Prickaerts, J., Steinbusch, H. & Ferrington, L. (2010). Acute tryptophan depletion potentiates MDMA-induced cerebrovascular hyperperfusion in adult male Wistar rats. Journal of Neuroscience Research, 88, 1557-1568. 9. van Donkelaar, E.L., Blokland A., Lieben, C.K.J., Kenis, G., Ferrington, L., Kelly, P.A.T., Steinbusch, H.W.M. & Prickaerts, J. (2010). Acute tryptophan depletion in healthy C57BL/6 mice does not induce reduction of central serotonin levels or affective behavioural changes. Neurochemistry International, 56, 21-34. 10. Olivier, J., Jans, L., Blokland, A., Broers, N., Homberg, J., Ellenbroek, B. & Cools, A.R. (2009). Serotonin transporter deficiency in rats contributes to impaired object memory. Genes, Brain and Behavior, 8, 829-834. 11. Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V.W., van Vark - van der Zee, L.C., Kuipers, F., Kiliaan, A.J., Blokland, A., Sijbrands, E., Sijbrands, K., Steinbusch, H.W., Prickaerts, J. & Lütjohann, D. (2011. Liver X Receptor activation restores memory in aged AD mice without reducing amyloid. Neurobiology of Aging, 32, 1262-1272. 12. van Donkelaar, E.L., Ferrington, L., Blokland, A., Steinbusch, H., Prickaerts, J. & Kelly, P.A.T. (2009). Acute tryptophan depletion in rats alters the relationship between cerebral blood flow and glucose metabolism independent of central serotonin. Neuroscience, 163, 683-694. 13. Lim, L.W., Temel, Y., Visser-Vandewalle, V., Blokland, A. & Steinbusch, H. (2009). Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter. Journal of Chemical Neuroanatomy, 38, 83-96. 14. van Donkelaar, E.L., van den Hove, D.L.A., Blokland, A., Steinbusch, H.W.M. & Prickaerts, J. (2009). Stress-mediated decreases in brain-derived neurotrophic factor as potential confounding factor for acute tryptophan depletion-induced neurochemical effects. European Neuropsychopharmacology, 19, 812-821. 15. Rutten, K., van Donkelaar, E.L., Ferrington, L., Blokland, A., Bollen, E., Steinbusch, H., Kelly, P.A.T. & Prickaerts, J.H.H.J. (2009). Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology, 34, 1914-1925. 16. Lemmens, E., Aendekerk, B., Schijns, O.E., Blokland, A., Beuls, E.A. & Hoogland, G. (2009). Long-term behavioural outcome after early-life hyperthermia-induced seizures. Epilepsy and Behavior, 14, 309-315. 17. Jans, L.A.W., Korte-Bouws, G.A.H, Korte, S.M. & Blokland, A. (2010). The effects of acute tryptophan depletion on affective behaviour and cognition in Brown Norway and Sprague Dawley rats Journal of Psychopharmacology, 24, 605-614. 18. van Donkelaar, E., Rutten, K., Blokland, A., Akkerman, S. Steinbusch, H. & Prickaerts, J. (2008). Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion. European Journal of Pharmacology, 600, 98-104. 19. Jans, L.A.W. & Blokland, A. (2008). Influence of chronic mild stress on the behavioural effects of acute tryptophan depletion induced by a gelatin-based mixture. Behavioural Pharmacology, 19, 706-715. 20. Jans, L.A.W., Lieben, C.K.J., Smits, L.T. & Blokland, A. (2009). Pharmacokinetics of acute tryptophan depletion using a gelatin based protein in male and female rats. Amino Acids, 37, 349-357. 21. Sesia, T., Temel, Y., Wei Lim, L., Blokland, A., Steinbusch, H.W.M. & Visser-Vandewalle, V. (2008). Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive action. Experimental Neurology, 214, 135-139. 22. van der Staay, F.J., Rutten, K., Bärfacker, L., DeVry, J., Erb, C., Heckroth, H., Karthaus, D., Tersteegen, A., van Kampen, M., Blokland, A., Prickaerts, J., Reymann, K.G., Schröder, U.H. & Hendrix, M. (2008). The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology, 55, 908-918. 23. Rutten, K., Misner, D., Works, M., Blokland, A., Novak, T.J., Santarelli, L. & Wallace-Boone, T. (2008). Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D knockout (PDE4D-/-) mice. European Journal of Neuroscience, 28, 625-632. 24. Lim, L.W., Temel, Y., Visser-Vandewalle, V., Sesia, T.,Vlamings, V., Steinbusch, H.W.M. & Blokland, A. (2008). Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats. Neuroscience, 155, 164-173. 25. Lim, L.W., Blokland, A., Visser-Vandewalle, V., Vlamings, R., Sesia, T., Steinbusch, H., Schruers, K., Griez, E., & Temel. Y. (2008). High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour. Behavioural Brain Research, 193, 197-203. 26. Olivier, J., Jans, L., Korte, G., Korte, S., Deen, P., Cools, A., Ellenbroek, B., & Blokland, A. (2008). Acute tryptophan depletion dose-dependently impairs object memory in serotonin transporter knockout rats. Psychopharmacology, 200, 243-254. 27. Rutten, K., Prickaerts, J., Schaenzle, G., Rosenbrock, H., & Blokland, A. (2008). Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats. Neurobiology of Learning and Memory, 90, 569-575. 28. Rutten, K., Reneerkens, O.A.H., Hamers, H., Şık, A., McGregor, I.S., Prickaerts, J. & Blokland, A. (2008). Automated scoring of novel object recognition in rats. Journal of Neuroscience Methods, 171, 72-77. 29. Abildayeva, K., Berbée, J.F.P., Blokland, A., Jansen, P.J., Hoek, F.J., Meijer, O., Lütjohann, D., Gautier, T., Pillot, T., De Vente, J., Havekes, L.M., Ramaekers, F.C.S., Kuipers, F., Rensen, P.C.N. & Mulder, M. (2008). Human Apolipoprotein CI Expression in Mice Impairs Learning and Memory Functions. Journal of Lipid Research, 49, 856-869. 30. Lim, L.W., Temel, Y., Visser-Vandewalle, V., Steinbusch, H., Schruers, K., Hameleers, R., Esquivel, G., Griez, E. & Blokland, A. (2008). Effect of Buspirone on the behavioral regulation of Wistar rats in low versus high anxiety condition. Arzneimittelforschung/Drug Research, 58, 269-276. 31. Rutten, K., Basile, J., Prickaerts, J., Blokland, A. & Vivian, J. (2008). Selective PDE inhibitors rolipram and sildenafil Improve object retrieval performance in adult cynomolgus macaques. Psychopharmacology, 96, 643-648. 32. Temel, Y., Booth, L., Blokland, A., Magill, P. Steinbusch, H. Visser-Vandewalle, V. & Sharp, T. (2007). Inhibition of 5-HT neurone activity and induction of depressive-like behaviour by high frequency stimulation of the subthalamic nucleus. Proceedings of the National Academy of Sciences USA, 104, 17087-17092. 33. Sambeth, A., Riedel, W.J., Tillie, D.E., Blokland, A., Postma, A. & Schmitt, J.A.J. (2009). Memory impairments in humans after acute tryptophan depletion using a novel gelatin-based protein drink. Journal of Psychopharmacology, 23, 56-64. 34. Van der Plasse, G., Meerkerk, D., Lieben, C., Blokland, A. & Feenstra, M. (2007). Lack of evidence for reduced prefrontal cortical serotonin and dopamine efflux after acute tryptophan depletion. Psychopharmacology, 195, 377-385. 35. Hameleers, R., Blokland, A., Steinbusch, H., Visser-Vandewalle, V. & Temel, Y. (2007). Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation. Behavioural Brain Research, 185, 65-67. 36. Mulder, M., Koopmans, G., Wassink, G., Al Mansouri, G., Havekes, L.M., Prickaerts, J. & Blokland, A. (2007). LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus. Neuroscience Research, 59, 251-256. 37. Sambeth, A., Riedel, W., Smits, L. & Blokland, A. (2007). Cholinergic drugs affect novel object recognition in rats: relation with hippocampal EEG? European Journal of Pharmacology, 572, 151-159. 38. Jans, L.A.W., Lieben, C. & Blokland, A. (2007). Influence of sex and estrus cycle on the effects of acute tryptophan depletion induced by a gelatin-based mixture in adult Wistar rats. Neuroscience, 147, 304-317. 39. Rutten, K., Lieben, C., Smits, L. & Blokland, A. (2007). The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat. Psychopharmacology, 192, 275-282. 40. Hoff, E.I., van Oostenbrugge, R.J., Liedenbaum, M., Steinbusch, H. & Blokland, A. (2007). Effects of right hemisphere cortical infarction and muscarinic acetylcholine receptor blockade on spatial visual attention performance in rats. Behavioural Brain Research, 178, 62-69. 41. Rutten, K., Prickaerts, J., Hendrix, M., van der Staay, F.J., Sik, A. & Blokland, A. (2007). Time dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors. European Journal of Pharmacology, 558, 107-112. 42. Schreiber, R., Vivian, J., Hedley, L., Szczepanski, K., Secchi, R., Zuzow, M., van Laarhoven, S. Moreau, J-L., Martin J.F., Sik, A. & Blokland, A. (2007). Effects of the novel 5-HT6 receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating. European Neuropsychopharmacology, 17, 277-288. 43. Temel, Y., Visser-Vandewalle, V., Kaplan, S., Kozan, R., Daemen, M.A.R.C., Blokland, A., Schmitz, C. & Steinbusch, H.W. (2006). Protection of nigral cell death by bilateral subthalamic nucleus stimulation. Brain Research, 1120, 100-105. 44. Temel, Y., Cao, C., Vlamings, R., Blokland, A., Ozen, H., Steinbusch, H.W., Michelsen, K.A., von Horsten, S., Schmitz, C. & Visser-Vandewalle, V. (2006). Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease. Neuroscience Letters, 406, 138-141. 45. Cao, C., Temel, Y., Blokland, A., Ozen, H., Steinbusch, H., Nguyen, H.P., von Horsten, S., Schmitz, C. & Visser-Vandewalle, V. (2006). Progressive deterioration of reaction time performance and choreatiform symptoms in Huntington's disease transgenic rats. Behavioural Brain Research, 170, 257-261. 46. Scholtissen, B., Deumens, R., Leentjens, A.F.G., Schmitz, C., Blokland, A., Steinbusch, H.W.M. & Prickaerts, J. (2006). Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-Hydroxydopamine lesioned rats. Pharmacology Biochemistry and Behavior, 83, 175-185. 47. Kantor, O., Temel, Y., Holzmann, C., Kerstin, R., Nguyen, H-P., Chao, C., Özen Türkoglu, H., Rutten, B.P.F., Visser-Vandewalle, V., Steinbusch, H.W.M., Blokland, A. Korr, H., Riess, O., von Hörsten, S. & Schmitz, C. (2006). Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats. Neurobiology of Disease, 22, 538-547. 48. Hoff, E.I., Blokland, A., Rutten, K., Steinbusch, H.W. & van Oostenbrugge, R.J. (2006). Dissociable effects in reaction time performance after unilateral cerebral infarction: a comparison between the left and right frontal cortices in rats. Brain Research, 1069, 182-189. 49. Lieben, C.K.J., Steinbusch, H. & Blokland, A. (2006). 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat. Behavioural Brain Research, 168, 197-207. 50. Rutten, K., Prickaerts, J. & Blokland, A. (2006). Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action. Neurobiology of Learning and Memory, 85, 132-138. 51. Temel, Y., Blokland, A., Ackermans, L., Boon, P., Vivianne H.J.M. van Kranen-Mastenbroek, V.H.J.M., Beuls, E.A.M., Spincemaille, G.H. & Visser-Vandewalle, V. (2006). Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance. Experimental Brain Research, 169, 389-399. 52. Rutten, K., De Vente, J., Sik, A., Markerink-van Ittersum, M., Prickaerts, J. & Blokland, A. (2005). The Selective PDE5 Inhibitor, Sildenafil, Improves Object Memory in Swiss Mice and Increases cGMP Levels in Hippocampal Slices. Behavioral Brain Research, 164, 11-16. 53. Lieben, C., Blokland, A., Şık, A., Sung, E., van Nieuwenhuizen, P. & Schreiber, R. (2005). Cognition-enhancing effects of the selective 5-HT6 receptor antagonist Ro4368554 in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology, 30, 2169-2179. 54. Temel, Y., Visser-Vandewalle, V., Aendekerk, B., Rutten, B., Tan, S., Scholtissen, B., Schmitz, C., Blokland, A. & Steinbusch, H. (2005). Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus. Experimental Neurology, 193, 43-52. 55. Prickaerts, J., Şık, A., Honig, W., van der Staay, F.J., de Vente, J. & Blokland, A. (2005). Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation. Psychopharmacology, 177, 381-390. 56. Boess, F.G., Hendrix, M., van der Staay, F.J., Erb, C., Schreiber, R., van Staveren, W., de Vente, J., Prickaerts, J., Blokland, A. & Koenig, G. (2004). Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology, 47, 1081-1092. 57. Temel, Y., Desbonnet, L., Visser-Vandewalle, V., Blokland, A., Hornikx, V. & Steinbusch, H. (2004). Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude- and frequency dependent. Brain Research, 1008, 198-204. 58. Mulder, M., Jansen, P.J. , Janssen, B.J.A., Van de Berg, W., van der Bloom, H., Havekes, L.M., de Kloet, E.R., Ramaekers, F. & Blokland, A. (2004). Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. Neurobiology of Disease, 16, 212-219. 59. Lieben, C., van Oorsouw, K., Deutz, N.E.P. & Blokland, A. (2004). Acute tryptophan depletion induced by a gelatin-based protein-carbohydrate mixture impairs object memory but not affective behavior and spatial learning in the rat. Behavioural Brain Research, 151, 53-64. 60. Lieben, C.K.J., Blokland, A., Westerink, B. & Deutz, N.E.P. (2004). Acute tryptophan depletion and serotonin depletion using an optimized tryptophan-free protein-carbohydrate mixture in the adult rat. Neurochemistry International, 44, 9-16. 61. Şık, A., van Nieuwenhuizen, P., Prickaerts, J. & Blokland, A. (2003). Performance of different mouse strains in an object recognition task. Behavioural Brain Research, 147, 49-54. 62. Koopmans, G., Blokland, A., van Nieuwenhuizen, P. & Prickaerts, J. (2003). Assessment of spatial learning abilities of mice in a new circular maze. Physiology & Behavior, 79, 683-693. 63. McGregor, I.S., Gurtman, C.G., Morley, K.C., Clemens, K.J., Blokland, A., Li, K.M., Cornish, J.L. & Hunt, G.E. (2003). Increased anxiety and “depressive” symptoms months after MDMA ("Ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. Psychopharmacology, 168, 465-474. 64. Hanning, C. D., Blokland, A., Johnson, M. & Perry, E. K. (2003). Effects of repeated anaesthesia on central cholinergic activity in elderly rats. European Journal of Anesthesiology, 20, 93-97. 65. Van de Berg, W.D.J., Kwaijtaal, M., De Louw, A., Lissone, N.P.A., Schmitz, C., Faull, R.L.M., Blokland, A., Blanco, C.E. & Steinbusch, H.W.M. (2003). Impact of perinatal asphyxia on motor behavior and the GABAergic system. Neuroscience, 117, 83-96. 66. Prickaerts, J., van Staveren, W., Sik, A., Markerink-van Ittersum, M., Niewohner, U., van der Staay, F.J., Blokland, A. & de Vente, J. (2002). Effects of inhibition of phosphodieserase type 5 on object recognition and hippocampal cyclic GMP levels. Neuroscience, 13, 351-361. 67. Prickaerts, J., de Vente, J., Honig, W., Steinbusch, H. & Blokland, A. (2002). Increasing hippocampal cGMP, but not cAMP, levels improves memory performance in an object recognition task in rats. European Journal of Pharmacology, 436, 83-87. 68. Mulder, M., Blokland, A., van den Berg, D.J., Schulten, H., Bakker, A.H.F., Terwel, D., Honig, W., de Kloet, E.R., Havekes, L.M., Steinbusch, H.W.M. & de Lange, E.C.M. (2001). Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. Laboratory Investigation, 81, 953-960. 69. Dom, R. & Blokland, A. (2000). Dementia. Neuroscience Research Communications, 26, 207-214. 70. Eijkenboom, M., Blokland, A. & van der Staay, F.J. (2000). Modeling cognitive dysfunctions with bilateral injections of ibotenic acid into the rat entorhinal cortex. Neuroscience, 101, 27-39. 71. Loidl, C.F., Gavilanes, A.W.D., Van Dijk, E.H.J., Vreuls, W., Blokland, A., Vles, J.S.H., Steinbusch, H.W.M. & Blanco, C.E. (2000). Effects of hypothermia and gender on survival and behavior after perinatal asphyxia in rats. Physiology & Behavior, 68, 263-269. 72. Prickaerts, J., de Vente, J., Steinbusch, H., Markerink-van Ittersum, M., Blokland, A. & Steinbusch, H. (2000). Role of nitric oxide in i.c.v. streptozotocin in rats. Journal of Neural Transmission, 107, 745-766. 73. van de Berg, W., Blokland, A., Cuello, A.C.,Schmitz, C., Vreuls, W., Steinbusch, H.W.M. & Blanco, C. (2000). Perinatal asphyxia results in changes in synaptic number in striatum and cerebellar cortex – a stereologic and behavioral analysis. Journal of Chemical Neuroanatomy, 20, 71-82. 74. Prickaerts, J., Fahrig,T. & Blokland, A. (1999). Cognitive performance and biochemical markers in hippocampus, septum and striatum after an i.c.v. injection of streptozotocin: a correlation analysis. Behavioural Brain Research, 102, 73-88. 75. Prickaerts, J., Honig, W., Schmidt, B.H. & Blokland, A. (1999). Metrifonate improves working but not reference memory performance in a spatial cone field task. European Journal of Pharmacology, 380, 61-65. 76. Prickaerts, J., Blokland, A., Bothmer, J., Honig, W., Markerink-van Ittersum, M. & Jolles, J. (1998). Effects of acute treatment with acetyl-l-carnitine on spatial discrimination learning in rats with NaCN-induced lowered energy metabolism. Neurochemistry International, 33, 419-427. 77. Klapdor, K. Blokland, A., Horváth, E. & van der Staay, F.J. (1997). Bilateral subdural hematoma in the rat: effects on performance in a visual discrimination task. Neuroscience Research Communications, 20, 79-84. 78. Hinz, V.C., Blokland, A., van der Staay, F.J., Gebert, I., Schuurman, T. & Schmidt, B.H. (1996). Receptor interaction profile and CNS general pharmacology of metrifonate and its transformation product dichlorvos in rodents. Drug Development Research, 38, 31-42. 79. Prickaerts, J., Raaijmakers, W. & Blokland, A. (1996). Effects of myocardial infarction and captopril therapy on anxiety-related behaviors in the rat. Physiology & Behavior, 60, 43-50.. 80. Van der Staay, F.J. & Blokland, A. (1996). Repeated assessment of spatial discrimination performance of aged rats in the Morris water escape task. Neurobiology of Learning and Memory, 65, 99-102. 81. Van der Staay, F.J. & Blokland, A. (1996). Behavioral differences between outbred Wistar, inbred Fischer 344, Brown Norway, and hybrid Fischer 344*Brown Norway rats. Physiology & Behavior, 60, 97-109. 82. Prickaerts, J., Blokland, A., Honig, W., Meng, F. & Jolles, J. (1995). Spatial discrimination learning and choline acetyltransferase activity in streptozotocin treated rats: Effects of chronic treatment with acetyl-l-carnitine. Brain Research, 674, 142-146. 83. Torres, E.M., Perry, T.A., Blokland, A., Wilkinson, L.S., Wiley, R.G., Lappi, D.A. & Dunnett, S.B. (1994). Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience, 63, 95-122. 84. Van der Staay, F.J., Blokland, A. & Raaijmakers, W. (1990). Different time course for age-related changes of behavior in a complex spatial cone-field discrimination task in Lewis rats. Psychobiology, 18, 305-311. 85. Van der Staay, F.J., Krechting, B., Blokland, A. & Raaijmakers, W.G.M. (1990). The cone field: a spatial discrimination task for the automatic and simultaneous assessment of working and reference memory in rats. Journal of Neuroscience Methods, 31, 13-22.
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BOOK
CHAPTERS
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1. Jans, L.A.W., & Blokland, A. (2008). Women and serotonergic vulnerability. In: W. Hansson, & E. Olson. (Eds.), New perspectives on women and depression. New York: Nova Science Publishers, pp. 267-293. 2. Schmidt, B.H., Hinc, V.C., Blokland, A., van der Staay, F.J., & Fanelli, R. (1996). Preclinical pharmacology of metrifonate: a promise for Alzheimer therapy. In: R. Becker, & E. Giacobini (Eds.), Alzheimer disease: From molecular biology to therapy. Boston: Birkhäuser, pp. 217-221.
3. Raaijmakers,
W.G.M., Blokland, A.,
Van der Staay, F.J., & Jolles, J. (1990). Differential
behavioral effects of chronic oral administration of Acetyl-L Carnitine in
young and old rats. In:
C.F.A. van Bezooijen, R. Ravid, & A.A.J. Verhofstad (Eds.), From
gene to man. Rijswijk: Stichting Gerontologie en Geriatrie, pp.
173-177.
4.
Raaijmakers, W.G.M., Van der Staay, F.J., Drinkenburg, W.H.I.M., & Blokland,
A. (1990). Age
differences and effects of lesion in the nucleus basalis magnocellularis
on a seven choice task in a radial alley maze. In: C.F.A. van Bezooijen, R. Ravid, & A.A.J.
Verhofstad (Eds.), From gene to man.
Rijswijk: Stichting Gerontologie en Geriatrie, pp. 159-163.
5. Van der Staay, F.J., Raaijmakers, W.G.M., & Blokland, A. (1990). Age differences in spatial memory of rats in two tasks
differing only for the response required to find and obtain the food
reward. In: C.F.A. van
Bezooijen, R. Ravid, & A.A.J. Verhofstad (Eds.), From
gene to man. Rijswijk: Stichting Gerontologie en Geriatrie, pp.
154-158.
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DUTCH PAPERS |
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1. Stapert, S. & Blokland, A. (2008). Hoe maakbaar is het brein? Functieherstel na niet-aangeboren hersenletsel vanuit neuropsychologisch en neurobiologisch perspectief. [How plastic is the brain? Functional recovery after acquired brain damage from a neuropsychological and neurobiological perspective] Tijdschrift voor Neuropsychologie, 3, 12-22.
2.
Blokland,
A. (2005). De biologie van het geheugen
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