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DISSERTATION

Blokland, A. (1992). Animal models of cognitive aging and dementia: problems and perspectives. Maastricht, DataWyse Publishers.

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RESEARCH PAPERS

First author 

1.  Blokland, A., Rutten, K., & Prickaerts, J. (2006). Analysis of spatial orientation strategies of male and female Wistar rats in a Morris water escape task. Behavioural Brain Research, 171, 216-224.

2.  Blokland, A., Şık, A. & Lieben, C. (2005). Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats. Behavioural Pharmacology, 16, 93-100.

3.  Blokland, A., Şık, A. & van der Staay, F.J. (2004). Delayed non-matching to position performance in aged hybrid Brown NorwayxFischer 344 rats: a longitudinal study. Brain Research Bulletin, 64, 39-46.

4.  Blokland, A., Lieben, C. Deutz, N.E.P. & Schmitt, J. (2004). Acute tryptophan depletion: comparing the effects of an amino acid mixture with a gelatin-based protein in man and rat. Current Topics in Nutraceutical Research, 2, 161-168.

5.  Blokland, A., Geraerts, E. & Been, M. (2004), A detailed analysis of rats’ spatial memory in a probe trial of a Morris task, Behavioural Brain Research, 154, 71-75.

6.  Blokland, A., Broersen, L.M., Uylings, H.B.M. & Jolles, J. (2003). Intact spatial discrimination performance but impaired reaction time performance after frontal cortex lesions in the rat. Neuroscience Research Communications, 33, 1-16.

7.  Blokland, A., Lieben, C. & Deutz, N. (2002). Anxiogenic and depressive like symptoms, but no cognitive deficits after acute tryptophan depletion in the rat. Journal of Psychopharmacology, 16, 39-49.

8.  Blokland, A., Scholtissen, B., Vermeeren, A. & Ramaekers, J. (2001). Dissociable effects of histamine H1 antagonists on reaction time performance in rats. Pharmacology Biochemistry and Behavior, 70, 427-436.

9.  Blokland, A., Honig, W., & Jolles, J. (2001). Long-term consequences of repeated anesthesia on reaction time performance in ageing rats. British Journal of Anaesthesia, 87, 781-783.

10.     Blokland, A., De Vente, J., Prickaerts, J., Honig, W., Markerink-van Ittersum, M., & Steinbusch, H. (1999). Local inhibition of hippocampal nitric oxide synthase does not impair place learning in the Morris water escape task in rats. European Journal of Neuroscience, 11, 223-232.

11.     Blokland, A. & Honig, W. (1999). Intra-striatal haloperidol and scopolamine injections: effects on choice reaction time performance in rats. European Neuropsychopharmacology, 9, 523-531.

12.     Blokland, A., Honig, W., Brouns, F. & Jolles, J. (1999). Cognition enhancing properties of subchronic bovine cortex, egg, and soy phosphatidylserine in middle-aged rats. Nutrition, 15, 778-783.

13.     Blokland, A. (1998). Involvement of striatal cholinergic receptors in reaction time and fixed interval responding in rats. Brain Research Bulletin, 45, 21-25.

14.     Blokland, A., Honig, W. & Prickaerts, J. (1998). Effects of haloperidol and amphetamine on working memory and reference memory in a spatial cone field task. Behavioural Pharmacology, 9, 429-436.

15.     Blokland, A., Prickaerts, J., Honig, W. & de Vente, J. (1998). State-dependent impairment in object recognition after hippocampal NOS inhibition. NeuroReport, 9,4205-4208.

16.     Blokland, A. & Dunnett, S.B. (1995). Development of response tendencies in the initial training trials of a (non)matching to position task: Consequences for learning the (non)matching to position task contingencies. Psychobiology, 23, 76 84.

17.     Blokland, A., Hinz, V. & Schmidt, B.H. (1995). Effects of metrifonate and tacrine in the spatial Morris task and modified Irwin test: evaluation of the efficacy/safety profile in rats. Drug Development Research, 36, 166-179.

18.     Blokland, A., Honig, W. & Raaijmakers, W. (1994). Age-related changes in spatial discrimination learning performance in old Lewis rats. Psychobiology, 22, 149-155.

19.     Blokland, A. & Jolles, J. (1994). Behavioral and biochemical effects of streptozotocin in old Lewis rats. Pharmacology Biochemistry and Behavior, 47, 833-837.

20.     Blokland, A., Bothmer, J., Honig, W. & Jolles, J. (1993). Behavioural and biochemical effects of acute central metabolic inhibition: effects of acetyl-l carnitine. European Journal of Pharmacology, 235, 275-281.

21.     Blokland, A. & Jolles, J. (1993). Spatial learning deficit and reduced hippocampal ChAT activity after an i.c.v. injection of streptozotocin. Pharmacology Biochemistry and Behavior, 44, 491-494.

22.     Blokland, A., Prickaerts, J. & Raaijmakers, W. (1993). Absence of impairments in spatial and temporal discrimination learning in Lewis rats after chronic ethanol consumption. Pharmacology Biochemistry and Behavior, 46, 27-34.

23.     Blokland, A. & Raaijmakers, W. (1993) Age-related changes in correlation between behavioral and biochemical parameters in Lewis rats. Behavioral and Neural Biology, 60, 52-61.

24.     Blokland, A. & Raaijmakers, W. (1993). Food motivation in rats of different ages. Psychobiology, 21, 228-232.

25.     Blokland, A., Honig, W. & Raaijmakers, W. (1992). The effect of intra hippocampal scopolamine injections in a repeated spatial acquisition task. Psychopharmacology, 109, 373-376.

26.     Blokland, A., Raaijmakers, W., Honig, W. & Van der Staay, F.J. (1992). Spatial discrimination learning and orientation strategy in young and old Lewis rats. Neuroscience Research Communications, 10, 105-110.

27.     Blokland, A., Prickaerts, J. & Raaijmakers, W.G.M. (1992). Reduced level of anxiety in adult Lewis rats after chronic ethanol consumption. Physiology & Behavior, 51, 245-248.

28.   Blokland, A., Raaijmakers, W., Van der Staay, F.J. & Jolles, J. (1990). Differential effect of acetyl-l-carnitine on open field behavior in young and old rats. Physiology & Behavior, 47, 783-785.

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RESEARCH PAPERS

Co-author 

1.         van Donkelaar, E., Kelly, P.A.T., Dawson, N., Blokland, A., Prickaerts, J., Steinbusch, H. & Ferrington, L. (in press). Acute tryptophan depletion potentiates MDMA-induced cerebrovascular hyperperfusion in adult male Wistar rats. Journal of Neuroscience Research.

2.         van Donkelaar, E.L., Blokland A., Lieben, C.K.J., Kenis, G., Ferrington, L., Kelly, P.A.T., Steinbusch, H.W.M. & Prickaerts, J. (in press). Acute tryptophan depletion in healthy C57BL/6 mice does not induce reduction of central serotonin levels or affective behavioural changes. Neurochemistry International.

3.         Olivier, J., Jans, L., Blokland, A., Broers, N., Homberg, J., Ellenbroek, B. & Cools, A.R. (in press). Serotonin transporter deficiency in rats contributes to impaired object memory. Genes, Brain and Behavior.

4.         Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V.W., van Vark - van der Zee, L.C., Kuipers, F., Kiliaan, A.J., Blokland, A., Sijbrands, E., Sijbrands, K., Steinbusch, H.W., Prickaerts, J. & Lütjohann, D. (in press). Liver X Receptor activation restores memory in aged AD mice without reducing amyloid. Neurobiology of Aging.

5.         van Donkelaar, E.L., Ferrington, L., Blokland, A., Steinbusch, H., Prickaerts, J. & Kelly, P.A.T. (2009). Acute tryptophan depletion in rats alters the relationship between cerebral blood flow and glucose metabolism independent of central serotonin. Neuroscience, 163, 683-694.

6.         Lee Wei Lim, L.W., Temel, Y., Visser-Vandewalle, V., Blokland, A. & Steinbusch, H. (2009). Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter. Journal of Chemical Neuroanatomy, 38, 83-96.

7.         van Donkelaar, E.L., van den Hove, D.L.A., Blokland, A., Steinbusch, H.W.M. & Prickaerts, J. (2009). Stress-mediated decreases in brain-derived neurotrophic factor as potential confounding factor for acute tryptophan depletion-induced neurochemical effects. European Neuropsychopharmacology, 19, 812-821.

8.         Rutten, K., van Donkelaar, E.L., Ferrington, L., Blokland, A., Bollen, E., Steinbusch, H., Kelly, P.A.T. & Prickaerts, J.H.H.J. (2009). Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology, 34, 1914-1925.

9.         Lemmens, E., Aendekerk, B., Schijns, O.E., Blokland, A., Beuls, E.A. &  Hoogland, G. (2009). Long-term behavioural outcome after early-life hyperthermia-induced seizures. Epilepsy and Behavior, 14, 309-315.

10.     Jans, L.A.W., Korte-Bouws, G.A.H, Korte, S.M. & Blokland, A. (in press). The effects of acute tryptophan depletion on affective behaviour and cognition in Brown Norway and Sprague Dawley rats Journal of Psychopharmacology.

11.     van Donkelaar, E., Rutten, K., Blokland, A. Akkerman, S. Steinbusch, H. & Prickaerts, J. (2008). Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion. European Journal of Pharmacology, 600, 98-104.

12.     Jans, L.A.W. & Blokland, A. (2008). Influence of chronic mild stress on the behavioural effects of acute tryptophan depletion induced by a gelatin-based mixture. Behavioural Pharmacology, 19, 706-715.

13.     Jans, L.A.W., Lieben, C.K.J., Smits, L.T. & Blokland, A. (2009). Pharmacokinetics of acute tryptophan depletion using a gelatin based protein in male and female rats. Amino Acids, 37, 349-357.

14.     Sesia, T., Temel, Y., Wei Lim, L., Blokland, A., Steinbusch, H.W.M. & Visser-Vandewalle, V. (2008). Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive action. Experimental Neurology, 214, 135-139.

15.     van der Staay, F.J., Rutten, K., Bärfacker, L., DeVry, J., Erb, C., Heckroth, H., Karthaus, D., Tersteegen, A., van Kampen, M., Blokland, A., Prickaerts, J., Reymann, K.G., Schröder, U.H. & Hendrix, M. (2008). The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology, 55, 908-918.

16.     Rutten, K., Misner, D., Works, M., Blokland, A., Novak, T.J., Santarelli, L. & Wallace-Boone, T. (2008). Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D knockout (PDE4D^-/-) mice. European Journal of Neuroscience, 28, 625-632.

17.     Lim, L.W., Temel, Y., Visser-Vandewalle, V., Sesia, T.,Vlamings, V., Steinbusch, H.W.M. & Blokland, A. (2008). Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats. Neuroscience, 155, 164-173.

18.     Lim, L.W., Blokland, A., Visser-Vandewalle, V., Vlamings, R., Sesia, T., Steinbusch, H., Schruers, K., Griez, E., & Temel. Y. (2008). High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour. Behavioural Brain Research, 193, 197-203.

19.     Olivier, J., Jans, L., Korte, G., Korte, S., Deen, P., Cools, A., Ellenbroek, B., & Blokland, A. (2008). Acute tryptophan depletion dose-dependently impairs object memory in serotonin transporter knockout rats. Psychopharmacology, 200, 243-254.

20.     Rutten, K., Prickaerts, J., Schaenzle, G., Rosenbrock, H., & Blokland, A. (2008). Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats. Neurobiology of Learning and Memory, 90, 569-575.

21.     Rutten, K., Reneerkens, O.A.H., Hamers, H., Şık, A., McGregor, I.S., Prickaerts, J. & Blokland, A. (2008). Automated scoring of novel object recognition in rats. Journal of Neuroscience Methods, 171, 72-77.

22.     Abildayeva, K., Berbée, J.F.P., Blokland, A., Jansen, P.J., Hoek, F.J., Meijer, O., Lütjohann, D., Gautier, T., Pillot, T., De Vente, J., Havekes, L.M., Ramaekers, F.C.S., Kuipers, F., Rensen, P.C.N. & Mulder, M. (2008). Human Apolipoprotein CI Expression in Mice Impairs Learning and Memory Functions. Journal of Lipid Research, 49, 856-869.

23.     Lim, L.W., Temel, Y., Visser-Vandewalle, V., Steinbusch, H., Schruers, K., Hameleers, R., Esquivel, G., Griez, E. & Blokland, A. (2008). Effect of Buspirone on the behavioral regulation of Wistar rats in low versus high anxiety condition. Arzneimittelforschung/Drug Research, 58, 269-276.

24.     Rutten, K., Basile, J., Prickaerts, J., Blokland, A. & Vivian, J. (2008). Selective PDE inhibitors rolipram and sildenafil Improve object retrieval performance in adult cynomolgus macaques. Psychopharmacology, 96, 643-648.

25.     Temel, Y., Booth, L., Blokland, A., Magill, P. Steinbusch, H. Visser-Vandewalle, V. & Sharp, T. (2007). Inhibition of 5-HT neurone activity and induction of depressive-like behaviour by high frequency stimulation of the subthalamic nucleus. Proceedings of the National Academy of Sciences USA, 104, 17087-17092.

26.     Sambeth, A., Riedel, W.J., Tillie, D.E., Blokland, A., Postma, A. & Schmitt, J.A.J. (in press). Memory impairments in humans after acute tryptophan depletion using a novel gelatin-based protein drink. Journal of Psychopharmacology, 23, 56-64.

27.     Van der Plasse, G., Meerkerk, D., Lieben, C., Blokland, A. & Feenstra, M. (2007). Lack of evidence for reduced prefrontal cortical serotonin and dopamine efflux after acute tryptophan depletion. Psychopharmacology, 195, 377-385.

28.     Hameleers, R., Blokland, A., Steinbusch, H., Visser-Vandewalle, V. & Temel, Y. (2007). Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation. Behavioural Brain Research, 185, 65-67.

29.     Mulder, M., Koopmans, G., Wassink, G.,  Al Mansouri, G., Havekes, L.M., Prickaerts, J. & Blokland, A. (2007). LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus. Neuroscience Research, 59, 251-256.

30.     Sambeth, A., Riedel, W., Smits, L. & Blokland, A. (2007). Cholinergic drugs affect novel object recognition in rats: relation with hippocampal EEG? European Journal of Pharmacology, 572, 151-159.

31.     Jans, L.A.W., Lieben, C. & Blokland, A. (2007). Influence of sex and estrus cycle on the effects of acute tryptophan depletion induced by a gelatin-based mixture in adult Wistar rats. Neuroscience, 147, 304-317.

32.     Rutten, K., Lieben, C., Smits, L. & Blokland, A. (2007). The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat. Psychopharmacology, 192, 275-282.

33.     Hoff, E.I., van Oostenbrugge, R.J., Liedenbaum, M., Steinbusch, H. & Blokland, A. (2007). Effects of right hemisphere cortical infarction and muscarinic acetylcholine receptor blockade on spatial visual attention performance in rats. Behavioural Brain Research, 178, 62-69.

34.     Rutten, K., Prickaerts, J., Hendrix, M., van der Staay, F.J., Sik, A. & Blokland, A. (2007). Time dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors. European Journal of Pharmacology, 558, 107-112.

35.     Schreiber, R., Vivian, J., Hedley, L., Szczepanski, K., Secchi, R., Zuzow, M., van Laarhoven, S. Moreau, J-L., Martin J.F., Sik, A. & Blokland, A. (2007). Effects of the novel 5-HT6 receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating. European Neuropsychopharmacology, 17, 277-288.

36.     Temel, Y., Visser-Vandewalle, V., Kaplan, S., Kozan, R., Daemen, M.A.R.C., Blokland, A., Schmitz, C. &  Steinbusch, H.W. (2006). Protection of nigral cell death by bilateral subthalamic nucleus stimulation. Brain Research, 1120, 100-105.

37.     Temel, Y., Cao, C., Vlamings, R., Blokland, A., Ozen, H., Steinbusch, H.W., Michelsen, K.A., von Horsten, S., Schmitz, C. & Visser-Vandewalle, V. (2006). Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease. Neuroscience Letters, 406, 138-141.

38.     Cao, C., Temel, Y., Blokland, A., Ozen, H., Steinbusch, H., Nguyen, H.P., von Horsten, S., Schmitz, C. & Visser-Vandewalle, V. (2006). Progressive deterioration of reaction time performance and choreatiform symptoms in Huntington's disease transgenic rats. Behavioural Brain Research, 170, 257-261.

39.     Scholtissen, B., Deumens, R., Leentjens, A.F.G., Schmitz, C., Blokland, A.,  Steinbusch, H.W.M. & Prickaerts, J. (2006). Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-Hydroxydopamine lesioned rats. Pharmacology Biochemistry and Behavior, 83, 175-185.

40.     Kantor, O., Temel, Y., Holzmann, C., Kerstin, R., Nguyen, H-P., Chao, C., Özen Türkoglu, H., Rutten, B.P.F., Visser-Vandewalle, V., Steinbusch, H.W.M., Blokland, A. Korr, H., Riess, O., von Hörsten, S. & Schmitz, C. (2006). Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats. Neurobiology of Disease, 22, 538-547.

41.     Hoff, E.I., Blokland, A., Rutten, K., Steinbusch, H.W. & van Oostenbrugge, R.J. (2006). Dissociable effects in reaction time performance after unilateral cerebral infarction: a comparison between the left and right frontal cortices in rats. Brain Research, 1069, 182-189.

42.     Lieben, C.K.J., Steinbusch, H. & Blokland, A. (2006). 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat. Behavioural Brain Research, 168, 197-207.

43.     Rutten, K., Prickaerts, J. & Blokland, A. (2006). Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action. Neurobiology of Learning and Memory, 85, 132-138.

44.     Temel, Y., Blokland, A., Ackermans, L., Boon, P., Vivianne H.J.M. van Kranen-Mastenbroek, V.H.J.M., Beuls, E.A.M., Spincemaille, G.H. & Visser-Vandewalle, V. (2006). Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance. Experimental Brain Research, 169, 389-399.

45.     Rutten, K., De Vente, J., Sik, A., Markerink-van Ittersum, M., Prickaerts, J. & Blokland, A. (2005). The Selective PDE5 Inhibitor, Sildenafil, Improves Object Memory in Swiss Mice and Increases cGMP Levels in Hippocampal Slices. Behavioral Brain Research, 164, 11-16.

46.     Lieben, C., Blokland, A., Şık, A., Sung, E., van Nieuwenhuizen, P. & Schreiber, R. (2005). Cognition-enhancing effects of the selective 5-HT6 receptor antagonist Ro4368554 in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology, 30, 2169-2179.

47.     Temel, Y., Visser-Vandewalle, V., Aendekerk, B., Rutten, B., Tan, S., Scholtissen, B., Schmitz, C., Blokland, A. & Steinbusch, H. (2005). Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus. Experimental Neurology, 193, 43-52.

48.     Prickaerts, J., Şık, A., Honig, W., van der Staay, F.J., de Vente, J. & Blokland, A. (2005). Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation. Psychopharmacology, 177, 381-390.

49.     Boess, F.G., Hendrix, M., van der Staay, F.J., Erb, C., Schreiber, R., van Staveren, W., de Vente, J., Prickaerts, J., Blokland, A. & Koenig, G. (2004). Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology, 47, 1081-1092.

50.     Temel, Y., Desbonnet, L., Visser-Vandewalle, V., Blokland, A.,  Hornikx, V. & Steinbusch, H. (2004). Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude- and frequency dependent. Brain Research, 1008, 198-204.

51.     Mulder, M., Jansen, P.J. , Janssen, B.J.A., Van de Berg, W., van der Bloom, H., Havekes, L.M., de Kloet, E.R., Ramaekers, F. & Blokland, A. (2004). Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. Neurobiology of Disease, 16, 212-219.

52.     Lieben, C., van Oorsouw, K., Deutz, N.E.P. & Blokland, A. (2004). Acute tryptophan depletion induced by a gelatin-based protein-carbohydrate mixture impairs object memory but not affective behavior and spatial learning in the rat. Behavioural Brain Research, 151, 53-64.

53.     Lieben, C.K.J., Blokland, A., Westerink, B. & Deutz, N.E.P. (2004). Acute tryptophan depletion and serotonin depletion using an optimized tryptophan-free protein-carbohydrate mixture in the adult rat. Neurochemistry International, 44, 9-16.

54.     Şık, A., van Nieuwenhuizen, P., Prickaerts, J. & Blokland, A. (2003). Performance of different mouse strains in an object recognition task. Behavioural Brain Research, 147, 49-54.

55.     Koopmans, G., Blokland, A., van Nieuwenhuizen, P. & Prickaerts, J. (2003). Assessment of spatial learning abilities of mice in a new circular maze. Physiology & Behavior, 79, 683-693.

56.     McGregor, I.S., Gurtman, C.G., Morley, K.C., Clemens, K.J., Blokland, A., Li, K.M., Cornish, J.L. & Hunt, G.E. (2003). Increased anxiety and “depressive” symptoms months after MDMA ("Ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. Psychopharmacology, 168, 465-474.

57.     Hanning, C. D., Blokland, A., Johnson, M. & Perry, E. K. (2003). Effects of repeated anaesthesia on central cholinergic activity in elderly rats. European Journal of Anesthesiology, 20, 93-97.

58.     Van de Berg, W.D.J., Kwaijtaal, M., De Louw, A., Lissone, N.P.A., Schmitz, C., Faull, R.L.M., Blokland, A., Blanco, C.E. & Steinbusch, H.W.M. (2003). Impact of perinatal asphyxia on motor behavior and the GABAergic system. Neuroscience, 117, 83-96.

59.     Prickaerts, J., van Staveren, W., Sik, A., Markerink-van Ittersum, M., Niewohner, U., van der Staay, F.J., Blokland, A. & de Vente, J. (2002). Effects of inhibition of phosphodieserase type 5 on object recognition and hippocampal cyclic GMP levels. Neuroscience, 13, 351-361.

60.     Prickaerts, J., de Vente, J., Honig, W., Steinbusch, H. & Blokland, A. (2002). Increasing hippocampal cGMP, but not cAMP, levels improves memory performance in an object recognition task in rats. European Journal of Pharmacology, 436, 83-87.

61.     Mulder, M., Blokland, A., van den Berg, D.J., Schulten, H., Bakker, A.H.F., Terwel, D., Honig, W., de Kloet, E.R., Havekes, L.M., Steinbusch, H.W.M. & de Lange, E.C.M. (2001). Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. Laboratory Investigation, 81, 953-960.

62.     Dom, R. & Blokland, A. (2000). Dementia. Neuroscience Research Communications, 26, 207-214.

63.     Eijkenboom, M., Blokland, A. & van der Staay, F.J. (2000). Modeling cognitive dysfunctions with bilateral injections of ibotenic acid into the rat entorhinal cortex. Neuroscience, 101, 27-39.

64.     Loidl, C.F., Gavilanes, A.W.D., Van Dijk, E.H.J., Vreuls, W., Blokland, A., Vles, J.S.H., Steinbusch, H.W.M. & Blanco, C.E. (2000). Effects of hypothermia and gender on survival and behavior after perinatal asphyxia in rats. Physiology & Behavior, 68, 263-269.

65.     Prickaerts, J., de Vente, J., Steinbusch, H., Markerink-van Ittersum, M., Blokland, A. & Steinbusch, H. (2000). Role of nitric oxide in i.c.v. streptozotocin in rats. Journal of Neural Transmission, 107, 745-766.

66.     van de Berg, W., Blokland, A., Cuello, A.C.,Schmitz, C., Vreuls, W., Steinbusch, H.W.M. & Blanco, C. (2000). Perinatal asphyxia results in changes in synaptic number in striatum and cerebellar cortex – a stereologic and behavioral analysis. Journal of Chemical Neuroanatomy, 20, 71-82.

67.     Prickaerts, J., Fahrig,T. & Blokland, A. (1999). Cognitive performance and biochemical markers in hippocampus, septum and striatum after an i.c.v. injection of streptozotocin: a correlation analysis. Behavioural Brain Research, 102, 73-88.

68.     Prickaerts, J., Honig, W., Schmidt, B.H. & Blokland, A. (1999). Metrifonate improves working but not reference memory performance in a spatial cone field task. European Journal of Pharmacology, 380, 61-65.

69.     Prickaerts, J., Blokland, A., Bothmer, J., Honig, W., Markerink-van Ittersum, M. & Jolles, J. (1998). Effects of acute treatment with acetyl-l-carnitine on spatial discrimination learning in rats with NaCN-induced lowered energy metabolism. Neurochemistry International, 33, 419-427.

70.     Klapdor, K. Blokland, A., Horváth, E. & van der Staay, F.J. (1997). Bilateral subdural hematoma in the rat: effects on performance in a visual discrimination task. Neuroscience Research Communications, 20, 79-84.

71.     Hinz, V.C., Blokland, A., van der Staay, F.J., Gebert, I., Schuurman, T. & Schmidt, B.H. (1996). Receptor interaction profile and CNS general pharmacology of metrifonate and its transformation product dichlorvos in rodents. Drug Development Research, 38, 31-42.

72.     Prickaerts, J., Raaijmakers, W. & Blokland, A. (1996). Effects of myocardial infarction and captopril therapy on anxiety-related behaviors in the rat. Physiology & Behavior, 60, 43-50..

73.     Van der Staay, F.J. & Blokland, A. (1996). Repeated assessment of spatial discrimination performance of aged rats in the Morris water escape task. Neurobiology of Learning and Memory, 65, 99-102.

74.     Van der Staay, F.J. & Blokland, A. (1996). Behavioral differences between outbred Wistar, inbred Fischer 344, Brown Norway, and hybrid Fischer 344*Brown Norway rats. Physiology & Behavior, 60, 97-109.

75.     Prickaerts, J., Blokland, A., Honig, W., Meng, F. & Jolles, J. (1995). Spatial discrimination learning and choline acetyltransferase activity in streptozotocin treated rats: Effects of chronic treatment with acetyl-l-carnitine. Brain Research, 674, 142-146.

76.     Torres, E.M., Perry, T.A., Blokland, A., Wilkinson, L.S., Wiley, R.G., Lappi, D.A. & Dunnett, S.B. (1994). Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience, 63, 95-122.

77.     Van der Staay, F.J., Blokland, A. & Raaijmakers, W. (1990). Different time course for age-related changes of behavior in a complex spatial cone-field discrimination task in Lewis rats. Psychobiology, 18, 305-311.

78.     Van der Staay, F.J., Krechting, B., Blokland, A. & Raaijmakers, W.G.M. (1990). The cone field: a spatial discrimination task for the automatic and simultaneous assessment of working and reference memory in rats. Journal of Neuroscience Methods, 31, 13-22.

BOOK CHAPTERS

1.  Jans, L.A.W., & Blokland, A. (in press). Women and serotonergic vulnerability. In: Women and Depression. New York: Nova Science Publishers.

2.  Schmidt, B.H., Hinc, V.C., Blokland, A., van der Staay, F.J., & Fanelli, R. (1996). Preclinical pharmacology of metrifonate: a promise for Alzheimer therapy. In: R. Becker, & E. Giacobini (Eds.), Alzheimer disease: From molecular biology to therapy. Boston: Birkhäuser, pp. 217-221.

3.    Raaijmakers, W.G.M., Blokland, A., Van der Staay, F.J., & Jolles, J. (1990). Differential behavioral effects of chronic oral administration of Acetyl-L Carnitine in young and old rats. In: C.F.A. van Bezooijen, R. Ravid, & A.A.J. Verhofstad (Eds.), From gene to man. Rijswijk: Stichting Gerontologie en Geriatrie, pp. 173-177.

4.    Raaijmakers, W.G.M., Van der Staay, F.J., Drinkenburg, W.H.I.M., & Blokland, A. (1990). Age differences and effects of lesion in the nucleus basalis magnocellularis on a seven choice task in a radial alley maze. In: C.F.A. van Bezooijen, R. Ravid, & A.A.J. Verhofstad (Eds.), From gene to man. Rijswijk: Stichting Gerontologie en Geriatrie, pp. 159-163.

5.    Van der Staay, F.J., Raaijmakers, W.G.M., & Blokland, A. (1990). Age differences in spatial memory of rats in two tasks differing only for the response required to find and obtain the food reward. In: C.F.A. van Bezooijen, R. Ravid, & A.A.J. Verhofstad (Eds.), From gene to man. Rijswijk: Stichting Gerontologie en Geriatrie, pp. 154-158.  

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DUTCH PAPERS

1.  Blokland, A. (2005). De biologie van het geheugen [The biology of memory]. Neuropraxis, 9, 137-141.