Homepage
of Martin Hoffmann
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BioMathematics
and BioInformatics Group |
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Department
of Knowledge Engineering |
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Boullionstraat
8-10 |
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6211
LH |
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Phone
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+31 43
38 83504 |
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Fax |
+31 43
38 84910 |
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E-mail |
martin
(dot) hoffmann (at) maastrichtuniversity (dot) nl |
Research Activities
·
Individual cell based modeling of cell cultures / tissue
formation
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Probabilistic modeling of biological systems
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Stem cell development
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Heart cell modeling
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Image analysis
Publications
PEER-REVIEWED JOURNALS
Spatial Organization of Mesenchymal Stem Cells in vitro - results from a new individual-cell based model with podia.
M. Hoffmann, J.-P. Kuska, M. Zscharnack, M. Loeffler, J. Galle.
PLoS ONE, 6(7): e21960. doi:10.1371/journal.pone.0021960, 2011. (publisher) (pdf)
Individual fates of mesenchymal
stem cells in vitro.
A.
Krinner, M. Hoffmann, M. Löffler, D. Drasdo, J. Galle.
BMC
Systems Biology, 4:73, 2010. (publisher)
(pdf)
Automated detection of
residual cells after sex-mismatched stem-cell transplantation - evidence for
presence of disease-marker negative residual cells.
J. Erlecke, I. Hartmann, M. Hoffmann, T. Kroll, H. Starke, A.
Heller, A. Gloria, H.G. Sayer,
T. Johannes, U. Claussen, T. Liehr, I.F. Loncarevic.
Molecular Cytogenetics, 2:12, 2009. (publisher) (pdf)
From single
cells to tissue architecture – a bottom-up approach to modelling the
spatio-temporal organisation of complex multi-cellular systems.
J. Galle, M. Hoffmann, G. Aust.
Journal of Mathematical Biology, 58(1-2):261-83, 2009. (publisher) (pdf)
Noise-driven stem cell and
progenitor population dynamics.
M. Hoffmann, H.H.
Chang, S. Huang, D. E. Ingber, M. Löffler, J. Galle.
PLoS ONE, 3(8): e2922.
doi:10.1371/journal.pone.0002922, 2008. (publisher) (pdf)
Robust computational
reconstitution – a new method for the comparative analysis of gene expression
in tissues and isolated cell fractions.
M.
Hoffmann, D. Pohlers, D. Koczan, H.-J. Thiesen, S. Wölfl, R. W. Kinne.
BMC Bioinformatics, 7:369, 2006. (publisher)
(pdf) (supplement.pdf)
Dynamic
Network Reconstruction from Gene Expression Data Applied to Immune Response
during Bacterial Infection.
R. Guthke, U. Möller, M. Hoffmann, F. Thies, S.
Töpfer.
Bioinformatics, 21(8), 1626-1634, 2005.
(publisher) (pdf)
Thermodynamics of membrane elasticity - A molecular
level approach to one- and two-component fluid amphiphilic membranes, Part I:
Theory.
M.
Hoffmann
European
Physical Journal E, Vol. 16, 111-123, 2005. (publisher) (pdf)
Thermodynamics of membrane elasticity - A molecular
level approach to one- and two-component fluid amphiphilic membranes, Part II:
Applications.
M.
Hoffmann
European
Physical Journal E, Vol. 16, 125-139, 2005. (publisher) (pdf)
Adaptive, Model-Based Control by the
Open-Loop-Feedback-Optimal (OLFO) Controller for the Effective Fed-Batch
Cultivation of Hybridoma Cells.
B. Frahm, P.
Lane, H. Atzert, A. Munack, M. Hoffmann, V.C. Hass, R. Pörtner.
Biotechnology
Progress, 18:1095-1103, 2002. (publisher) (pdf)
PEER-REVIEWED PROCEEDINGS
Noise-driven stem cell and
progenitor population dynamics.
M. Hoffmann, J.
Galle.
Proceedings of the 8th German
Workshop on Artificial Life, GWAL-8, eds. K. Klemm, D. Merkle,
E. Olbrich, 63-72, 2008.
Optimized alignment and
visualization of clustering results.
M.
Hoffmann, D. Radke, U. Möller.
Advances in Data Analysis, eds. R. Decker, H.-J. Lenz. Series:
Studies in Classification,
Data
Analysis, and Knowledge Organization, Vol. 33, Springer Heidelberg-Berlin,
75-82, 2007. (publisher) (pdf)
CITABLE PROCEEDINGS
Model-Based Control of Hybridoma
Cell Cultures.
V.C. Hass,
Proceedings
of the IFAC CAB8 - 8th International Conference on Computer
Applications in
The bending elasticity of charged
amphiphilic membranes – constant dissociation versus constant dissociation
constant.
M.
Hoffmann, S. May.
Proceedings of the 13th School on
Biophysics of Membrane Transport, eds. J. Kuczera et al.,
Interaktion von spontanen otoakustischen
Emissionen.
S.
Uppenkamp, M. Hoffmann.
Fortschritte
der Akustik - DAGA 1997, ed. Wille, DEGA e.V.,
SUBMITTED MANUSCRIPTS
Mesenchymal Stem Cell Heterogeneity and Ageing in vitro ‐ a Model Approach.
J. Galle, M. Hoffmann, A. Krinner
Histology and Histopathology,
submitted in June 2011.
THESES
PhD Thesis
Thermodynamics of amphiphilic
membranes using molecular models. (library link) (pdf)
Supervisors:
S. May, G. Kluge, A. Köhler
Diploma Thesis
Time
series prediction and control of autonomous wind diesel systems using neural
networks.
Supervisors:
J. Luther, P. Rujan, T. Degner.
Student Research
Project
Chaos
with a parametrically excited heavy symmetrical top.
Supervisors:
H.-J. Schellnhuber, P. Kappertz.
Short CV
WORK EXPERIENCE
2009 – present Biomathematics and Bioinformatics Group,
Department of Knowledge Engineering, Postdoc
2006 – 2009 Interdisciplinary Centre for Bioinformatics, Postdoc
2004 – 2006 Junior Research Group: Bioinformatics/Pattern Recognition,
Postdoc
Leibniz
Institute for Natural Product Research and Infection Biology –
2001 – 2004 Department of Molecular and Applied Microbiology, Postdoc
Leibniz
Institute for Natural Product Research and Infection Biology –
2000 – 2001 Department of Medical Technology and Biotechnology,
Postdoc, Lecturer
University
of Applied Sciences
1996 – 1999 Institute for Biochemistry and Biophysics, Collaborative
Research Centre SFB 197 ‘Bio- and Modelmembranes’, PhD student
HIGHER EDUCATION
1996 – 1999 PhD study, Doctoral degree in Physics (2002)
1990 – 1995 Study of physics, Diploma in Physics (1995)
1988 – 1990 Study of Physics and Mathematics, Intermediate Diploma in
Physics (1990) and Mathematics (1990)
1982 – 1985 Vocational training in Sports and Physiotherapy,
Physiotherapist (1985), Sports Teacher (1985)
Vocational
School for Sports and Physiotherapy,